Animal model for experimental Lassa fever vaccine

August 09, 2018

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The authors developed a vaccine candidate against Lassa fever virus that combines the scalability and efficacy of a live vaccine with the safety benefits of single-cycle replication. Their system consists of Lassa virus replicon particles that do not contain the virus essential glycoprotein gene, and a cell line that expresses glycoprotein products, thereby enabling efficient vaccine propagation. Guinea pigs vaccinated with these particles did not display any clinical reaction to the vaccine but were protected against fever, weight loss and death following infection with Lassa fever virus.

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Kainulainen MH, Spengler JR, Welch SR, Coleman-McCray JD, Harmon JR, et al. ISSN: J Infect Dis; 217(12): 1957-1966


Added: August 09, 2018