Association between HIV and lung cancer

February 13, 2017

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Previous studies have found that infection with HIV is independently associated with risk of lung cancer but the link between longitudinal immune function and this cancer risk is still unclear. The authors followed up participants with HIV from the Veterans Aging Cohort Study for a minimum of 3 years and used cancer registry data to identify incident cases of lung cancer. They identified 277 cases of incident lung cancer in 21,666 patients with HIV. They developed Cox regression models separately for each time-updated 12 month lagged, 24 month simple moving average cumulative exposure and found that increased risk of lung cancer was significantly associated with low CD4 cell counts, low CD4/CD8 ratio, high HIV RNA concentration and more cumulative bacterial pneumonia episodes. When all of these factors were adjusted, the low CD4/CD8 ratio and high number of cumulative bacterial pneumonia episodes remained significant. Therefore there is evidence that dysfunctional immune activation and chronic inflammation may be contributing to the development of lung cancer in HIV-infected patients

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Sigel K, Wisnivesky J, Crothers K, Gordon K, Brown ST, et al. ISSN: Lancet HIV; pii: S2352-3018(16)30215-6


Added: February 13, 2017