News

Effect if hepatitis C virus treatment on carotid atherosclerosis

August 08, 2018

Share article

Some recent studies have found an association between hepatitis C virus (HCV) infection and cardiovascular disease, including carotid atherosclerosis. The authors were interested in whether HCV eradication using direct-acting antivirals (DAA) improves carotid atherosclerosis in HCV-infected patients with advanced fibrosis/compensated cirrhosis. They enrolled 182 consecutive patients with HCV and advanced fibrosis or compensated cirrhosis. All patients were treated with DAAs according to AISF/EASL guidelines. Intima-media thickness (IMT), carotid thickening (IMT ≥1 mm) and carotid plaques (focal thickening of ≥1.5 mm at the level of the common carotid), were assessed using ultrasonography (US) at baseline and 9-12 months following the end of therapy. 56% of patients were male, their mean age was 63.1 years and 65.9% had compensated cirrhosis. 20% had diabetes, 14.3% were obese, 41.8% had arterial hypertension and 35.2% were smokers. At baseline, the mean IMT was 0.94 mm, 42.8% had IMT ≥1 mm and 42.8% had carotid plaques. All of the patients achieved a sustained virologic response 12 weeks following end of therapy. IMT significantly decreased from baseline to follow-up (0.94 mm vs. 0.81 mm). There was also a significant reduction in the prevalence of patients with carotid thickening from baseline to follow-up (42.8% vs. 17%), while no changes were seen for carotid plaques. Therefore HCV eradication using DAAs improves carotid atherosclerosis in patients with severe fibrosis with or without additional metabolic risk factors.

Read more here

Petta S, Adinolfi LE, Fracanzani AL, Rini F, Caldarella R, et al. ISSN: J Hepatol; 69(1): 18-24

2018

Added: August 08, 2018