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Epidemiology and clinical characteristics of first 99 2019-novel coronavirus cases

February 10, 2020

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The authors describe the epidemiological and clinical characteristics of the 2019 novel coronavirus (2019-nCoV) pneumonia cases. They conducted a retrospective, single-centre study examining all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital. Of the 99 patients with 2019-nCoV pneumonia, 49% had a history of exposure to the Huanan seafood market. The average age of the patients was 55ยท5 years and consisted of 67 men and 32 women. 2019-nCoV was detected in all patients using real-time RT-PCR. 51% of patients had chronic diseases. Clinical manifestations included: fever (83% patients), cough (82%), shortness of breath (31%), muscle ache (11%), confusion (9%), headache (8%), sore throat (5%), rhinorrhoea (4%), chest pain (2%), diarrhoea (2%), and nausea and vomiting (1% of patients). On imaging, 75% of patients had bilateral pneumonia, 14% had multiple mottling and ground-glass opacity, and 1% had a pneumothorax. 17% of patients developed acute respiratory distress syndrome and, of these, 11% died of multiple organ failure. Therefore 2019-nCoV infection appears to be more likely to affect older males with comorbidities, and can result in severe and fatal respiratory diseases. The characteristics of patients who died tended to be in line with their MuLBSTA score, an early warning model for predicting mortality in viral pneumonia.

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Chen N, Zhou M, Dong X, Qu J, Gong F, et al. ISSN: Lancet; pii: S0140-6736(20)30211-7

2020

Added: February 10, 2020