Host genetic variations can modify the rate at which HIV-1 is acquired and therefore is important knowledge for the development of HIV prevention strategies. Currently the associations between rare or intermediate-frequency variants and HIV acquisition have not been well studied. The authors examined the association between variation in genic regions and extreme HIV-acquisition phenotypes in 100 sub-Saharan Africans using whole genome sequencing. They found that missense variants in the immunoglobulin-like regions of CD101 and, among women, one missense/5’ UTR variant in UBE2V1, were significantly associated with increased risk of HIV acquisition. Both of these genes are known to impact host inflammatory pathways. The effect sizes increased with exposure to HIV after adjusting for the independent effect of increasing exposure on acquisition risk. Therefore the presence of this variants is important to ascertain at a patient and population level.
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