Recent studies have suggested that statins may be associated with an increased influenza risk among recipients of the influenza vaccine. The authors used Medicare data to examine the associations between statins and risks of influenza among vaccine recipients. They performed a retrospective cohort study of patients aged >65 years who have received high-dose (HD) or standard-dose (SD) influenza vaccines from 2010-11 to 2014-15. Altogether 1,403,651 statin users were matched to non-users. For statin users, compared with non-users, the adjusted relative risk of influenza-related visits was 1.086 (95%CI 1.025-1.150) and for influenza-related hospitalisations was 1.096 (95%CI 1.013-1.185). The risk difference ranged from -0.02 to 0.23 for influenza-related visits and from -0.04 to 0.13 for hospitalisations, depending upon the season severity. Results were similar for HD and SD recipients, and for non-synthetic and synthetic statin users. Therefore it does not appear that statin use around the time of influenza vaccination does not substantially affect the risk of influenza-related medical encounters among older adults.
Read more here