Hepatitis C virus (HCV) incidence among HIV-infected men who have sex with men (MSM) has increased since 2000. The authors wanted to examine these trends and assess the association between incidence and geographical region, age and HIV-related measurements. They used data from the CASCADE Collaboration (1990-2014). Of 5941 HIV-infected MSM, 337 acquired HCV during follow-up. The authors found that HCV incidence significantly increased from 0.7/1,000 person-years in 1990 to 18/1,000 person-years in 2014. Significant associations with HCV incidence were recent calendar years, younger age, recent HIV infection and higher HIV RNA levels. Trends did differ by geographical region with incidence stabilising in Western Europe and remaining stable in Southern Europe, while continuing to increase in Northern Europe. Time from HIV to HCV infection significantly decreased over time. Therefore HCV has continued to spread among HIV-infected MSM in recent years.
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