When epidemiological investigations of nosocomial influenza virus transmission have previously been undertaken, they often focus on the identification of patients who share the same influenza virus type and who have overlapped in time and place. However, the authors were concerned that this method may misidentify transmission where it has not occurred or miss transmission when it has. Instead they used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a haematology/oncology ward and were able to identify two separate introductions, one of which resulted in five additional infections and 79 bed-days lost. Therefore the use of WGS to support traditional epidemiology can help identify where there have been failures within infection control procedures.
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